Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease
نویسندگان
چکیده
منابع مشابه
Aspirin Exacerbated Respiratory Disease
As guest editors of this special issue of the Journal of Allergy, we are pleased to be able to present a range of articles, both reviews and original research papers, on the important topic of aspirin-exacerbated respiratory disease (AERD). AERD is a synonym for the " aspirin triad " of asthma, nasal polyposis and sensitivity to aspirin originally described by Widal ninety years ago. AERD patie...
متن کاملClinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease
This study aimed to investigate the efficacy and the underlining mechanism of aspirindesensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirtyeightpatients, who had undergone an aspirin challenge test and were diagnosed as havingAERD, were engaged in a double-blind randomized clinical trial. They were divided into twogroups—an active group of patients who went t...
متن کاملClinical and Immunological Efficacy of Aspirin Desensitization in Nasal Polyp Patients with Aspirin-Exacerbated Respiratory Disease
This study aimed to investigate the efficacy and the underlining mechanism of aspirindesensitization among patients with Aspirin Exacerbated Respiratory Disease (AERD). Thirtyeightpatients, who had undergone an aspirin challenge test and were diagnosed as havingAERD, were engaged in a double-blind randomized clinical trial. They were divided into twogroups—an active group of patients who went t...
متن کاملGenetic Mechanisms in Aspirin-Exacerbated Respiratory Disease
Aspirin-exacerbated respiratory disease (AERD) refers to the development of bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs. The key pathogenic mechanisms associated with AERD are the overproduction of cysteinyl leukotrienes (CysLTs) and increased CysLTR1 expression in the airway mucosa and decreased lipoxin and PGE2 synthesis. G...
متن کاملImmunomodulatory treatments for aspirin exacerbated respiratory disease
BACKGROUND Aspirin triad is a subclass of chronic sinusitis characterized by nasal polyposis, nonallergic induced asthma, and aspirin sensitivity. Also known as Samter's triad or aspirin-exacerbated respiratory disease, aspirin triad commonly affects the adult population and is seldom found in pediatric patients. METHODS This rhinosinusitis has multiple layers of pathological process, but th...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2016
ISSN: 2092-6413
DOI: 10.1038/emm.2015.96